Development of the reference material of the multicomponent solution of elements ICP-RM Multi 2 for inductively coupled plasma methods.

For the metrological assurance of inductively coupled plasma mass spectrometry and inductively coupled plasma optical emission spectrometry, the process of establishing the calibration dependence of the output signal is of great importance. In this article, the authors present the results of work on the development of a reference material of the composition of a multicomponent solution of elements: barium, cadmium, cobalt, copper, iron, lead, lithium, manganese, nickel and zinc (ICP-RM Multi 2). The reference material is a solution of metals or their compounds acidified with nitric acid and packaged in cans made high pressure polyethylene complete with a hermetically sealed screw cap for long-term storage, with additional packaging of the lid in paraffin tape and vacuum packaging to reduce evaporation of the material through a threaded connection. This article presents the results of determining the metrological characteristics of reference material: long-term stability, homogeneity and uncertainty of characterization of the certified value based on the results of measurements on the State primary Standard of units of mass fraction and mass (molar) concentration of inorganic components in aqueous solutions based on gravimetric and spectral methods GET 217-2018. Тhe extended uncertainty of the certified value of the mass fraction and mass concentration of components in ICP-RM Multi 2 does not exceed 0.8 %, which corresponds to the category of working standards according to the state verification scheme of component content and will ensure metrological traceability of measurement results in inorganic analysis by mass spectrometry and optical emission spectrometry with inductively coupled plasma methods from the State primary standard GET 217-2018, and also to apply in routine analysis one of the main advantages of these methods is the ability to quickly and simultaneously measure several elements in samples.

1. Stakheev A. A., Stolboushkina T. P. Development and testing of a multi-element ICP standard. Measurement Standards. Reference Materials, 17(2), 49–57 (2021). (In Russ.) https://doi.org/10.20915/2687-0886-2021-17-2-49-57

2. Stolboushkina T. P., Stakheev A. A. Determination of zinc, copper, cadmium and lead in beef liver. Analytics, 14(2), 162–166 (2024). (In Russ.) https://doi.org/10.22184/2227-572X.2024.14.2.162.166

3. Wang J. Final report of the CCQM-K145: toxic and essential elements in bovine liver. Metrologia, 57(1A), 08013 (2020). https://doi.org/10.1088/0026-1394/57/1A/08013

4. Yang L. Final report of the SIM.QM-S7 supplementary comparison, trace metals in drinking water. Metrologia, 55(1A), 08002 (2018). https://doi.org/10.1088/0026-1394/55/1A/08002

5. Jackson S. L. Determination of Mn, Fe, Ni, Cu, Zn, Cd and Pb in seawater using offline extraction and triple quadrupole ICP-MS/MS. Journal of Analytical Atomic Spectrometry, 33(2) (2018). https://doi.org/10.1039/C7JA00237H

6. Belkouteb N., Schroeder H., Arndt J. et al. Quantification of 68 elements in river water monitoring samples in single-run measurements. Chemosphere, 320, 138053 (2023). https://doi.org/10.1016/j.chemosphere.2023.138053

7. Belkouteb N., Schroeder H., Wiederhold J. G. et al. Multi-element analysis of unfiltered samples in river water monitoring digestion and single-run analyses of 67 elements. Analytical and bioanalytical chemistry, 416, 3205–3222 (2024). https://doi.org/10.1007/s00216-024-05270-4

8. Ma L. D., Wang Q., Wei C. et al. Measurement of heavy metals and organo-tin in leather powder. Metrologia, 55(1A), 08020 (2018). https://doi.org/10.1088/0026-1394/55/1A/08020

9. Legat J., Matczuk M., Timerbaev A., Jarosz M. CE separation and ICP-MS detection of gold nanoparticles and their protein conjugates. Chromatographia, 80(11), 1–6 (2017). https://doi.org/10.1007/s10337-017-3387-y

10. Kruszewska J., Matczuk M., Skorupska S., et al. Characterization of quantum dots in cancer cytosol using ICP-MS based combined techniques. Analytical Biochemistry, 584, 113387 (2019). https://doi.org/10.1016/j.ab.2019.113387

11. Matczuk M., Ruzik L., Timerbaev A. R. Recent development of CE-ICP-MS in biospeciation research and analysis: From anticancer drugs to nanoparticles and beyond TrAC. Trends in Analytical Chemistry, 180, 117967 (2024). https://doi.org/10.1016/j.trac.2024.117967

12. Wang X.Y., Zuo Y., Huang D. et al. Comparative study on inorganic composition and crystallographic properties of cortical and cancellous bone. Biomedical and Environmental Sciences, 23(6), 473–480 (2010). https://doi.org/10.1016/S0895-3988(11)60010-X

13. Seltzer M. D., Lance V. A., Elsey R. M. Laser ablation ICP-MS analysis of the radial distribution of lead in the femur of Alligator mississippiensis. The Science of The Total Environment, 363(1-3), 245–252 (2006). https://doi.org/10.1016/j.scitotenv.2005.05.024

14. Gusev L. Yu., Stakheev A. A. On the uniformity of measurements in the field of mass spectrometry. Al’manac of Modern Metrology, (6), 49–52 (2016). (In Russ.) https://elibrary.ru/wiqkkx

15. Dobrovol’skii V. I., Stakheev A. A., Stolboushkina T. P. GET 217-2018: State primary standard of unit of mass fraction and unit of mass (molar) concentration of inorganic components in aqueous solutions based on gravimetric and spectral methods. Measurement Techniques, 61(11), 1041–1044 (2019). https://doi.org/10.1007/s11018-019-01546-9

16. Stolboushkina T. P., Stakheev A. A. The cleanliness of laboratory glassware is the key to reliable and accurate measurements. Al’manac of Modern Metrology, (14), 201–205 (2018). (In Russ.) https://elibrary.ru/kzdhxy

17.