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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">izmertech</journal-id><journal-title-group><journal-title xml:lang="ru">Измерительная техника</journal-title><trans-title-group xml:lang="en"><trans-title>Izmeritel`naya Tekhnika</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0368-1025</issn><issn pub-type="epub">2949-5237</issn><publisher><publisher-name>ФГУП "ВНИИФТРИ"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.32446/0368-1025it.2021-9-62-67</article-id><article-id custom-type="elpub" pub-id-type="custom">izmertech-1949</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕДИЦИНСКИЕ И БИОЛОГИЧЕСКИЕ ИЗМЕРЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MEDICAL AND BIOLOGICAL MEASUREMENTS</subject></subj-group></article-categories><title-group><article-title>Модель оценки неоднородности распределения характеристик глобул на изображениях новообразований кожи</article-title><trans-title-group xml:lang="en"><trans-title>Model for estimating the heterogeneity of the distribution of globule characteristics in images of skin neoplasms</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4349-3023</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитаев</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikitaev</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Валентин Григорьевич Никитаев</p><p>Москва</p></bio><bio xml:lang="en"><p>Valentin G. Nikitaev</p><p> Moscow</p></bio><email xlink:type="simple">vgnikitayev@mephi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0443-8504</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Проничев</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Pronichev</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Александр Николаевич Проничев</p><p>Москва</p></bio><bio xml:lang="en"><p>Alexandr N. Pronichev</p><p>Moscow</p></bio><email xlink:type="simple">anpronichev@mephi.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3261-6718</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тамразова</surname><given-names>О. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Tamrazova</surname><given-names>O. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Борисовна Тамразова</p><p>Москва</p></bio><bio xml:lang="en"><p>Olga B. Tamrazova</p><p>Moscow</p></bio><email xlink:type="simple">anait_tamrazova@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8487-137X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сергеев</surname><given-names>В. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Sergeev</surname><given-names>V. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Василий Юрьевич Сергеев</p><p>Москва</p></bio><bio xml:lang="en"><p>Vasily Yu. Sergeev</p><p>Moscow</p></bio><email xlink:type="simple">vasesergeevu@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2306-8959</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сельчук</surname><given-names>В. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Selchuk</surname><given-names>V. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владимир Юрьевич Сельчук</p><p>Москва</p></bio><bio xml:lang="en"><p>Vladimir Yu. Selchuk</p><p>Moscow</p></bio><email xlink:type="simple">selvu@mail.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1418-6278</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлов</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlov</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владимир Сергеевич Козлов</p><p>Москва</p></bio><bio xml:lang="en"><p>Vladimir S. Kozlov</p><p>Moscow</p></bio><email xlink:type="simple">vskozlov@mephi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5218-0478</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лим</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Lim</surname><given-names>A. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алина Олеговна Лим</p><p>Москва</p></bio><bio xml:lang="en"><p>Alina O. Lim</p><p>Moscow</p></bio><email xlink:type="simple">alinalim30@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный исследовательский ядерный университет «МИФИ»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Research Nuclear University “MEPhI” (Moscow Engineering Physics Institute)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальный исследовательский ядерный университет «МИФИ»; &#13;
Национальный исследовательский ядерный университет «МИФИ»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Research Nuclear University “MEPhI” (Moscow Engineering Physics Institute)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Российский университет дружбы народов</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Peoples' Friendship University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Центральная государственная медицинская академия Управления делами Президента Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central State Medical Academy of the Administrative Department of the President of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет им. А. И. Евдокимова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Research Nuclear University “MEPhI” (Moscow Engineering Physics Institute);&#13;
A. I. Yevdokimov Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>15</day><month>08</month><year>2023</year></pub-date><volume>0</volume><issue>9</issue><fpage>62</fpage><lpage>67</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; ФГУП "ВНИИФТРИ", 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">ФГУП "ВНИИФТРИ"</copyright-holder><copyright-holder xml:lang="en">ФГУП "ВНИИФТРИ"</copyright-holder><license xlink:href="https://www.izmt.ru/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://www.izmt.ru/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://www.izmt.ru/jour/article/view/1949">https://www.izmt.ru/jour/article/view/1949</self-uri><abstract><p>Рассмотрена проблема диагностики меланомы кожи по цифровым изображениям опухоли. Кратко описаны клинические алгоритмы выявления меланомы кожи. Дан обзор работ, посвящённых автоматизированной оценке асимметрии распределения формы, цвета, площади глобул – важных признаков меланомы. Разработана модель оценки неоднородности распределения характеристик глобул на цифровых изображениях при диагностике новообразований кожи и предложены модели признаков неоднородности указанного распределения. Проведена экспериментальная сравнительная оценка моделей признаков с помощью программной системы, разработанной на языке С++. Определены наиболее информативные признаки неоднородности распределения характеристик глобул. Максимальная (93 %) точность оценки неоднородности распределения характеристик глобул получена для признака «приведённая обратная величина наибольшей частоты появления измеренных площадей глобул». Результаты исследования могут быть полезны при разработке систем поддержки принятия врачебных решений при диагностике меланомы.</p></abstract><trans-abstract xml:lang="en"><p>The problem of skin melanoma diagnostics from digital images of the tumor is considered. Clinical algorithms for detecting skin melanoma are briefly described. An overview of the works devoted to the automated assessment of the asymmetry of the distribution of shape, color, area of globules – important signs of melanoma – is given. A model for estimating the heterogeneity of the distribution of the characteristics of globules on digital images in the skin neoplasms diagnosis is developed and models of signs of heterogeneity of this distribution are proposed. The comparative evaluation of the proposed models was carried out experimentally using a software system developed in C++. The most informative features are identified. The greatest accuracy 93 % in estimating the heterogeneity of the distribution of the characteristics of globules was shown by the sign “the reduced inverse of the greatest frequency of occurrence of the measured areas of globules”. The results obtained can be applied in the development of systems to support medical decision-making in the diagnosis of melanoma.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>новообразования кожи</kwd><kwd>диагностика меланомы</kwd><kwd>признаки неоднородности</kwd><kwd>характеристики глобул</kwd><kwd>цифровая обработка изображений</kwd></kwd-group><kwd-group xml:lang="en"><kwd>skin neoplasms</kwd><kwd>diagnosis of melanoma</kwd><kwd>signs of heterogeneity</kwd><kwd>characteristics of globules</kwd><kwd>digital image processing</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Каприн А. Д., Старинский В. В., Петрова Г. В. 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